ABCDEFGHIJKLMNOPQRSTUVWXYZ
1
Introduction to Queries Supporting Potential Drug-drug Interaction (PDDI) Management
2
Assume a patient, Pt with conditions, Conds, currently taking drugs, D, and being prescribed drug Rx. Then, any or a combination of the following queries may assist in predicting, estimating the magnitude of, and proposing management strategies for a potential drug-drug interaction (PDDI)
3
4
5
QueryComment
6
Queries related to Metabolic PDDIsDan Malone
7
#N/Aprobably need to include transport proteins to list of metabolic pathways
8
9
10
11
12
13
14
15
16
17
Physiologic
18
#N/A
19
20
21
22
Transport
23
#N/A
24
25
26
27
28
Composite Drug Interactions
29
#N/A
30
31
Pharmacodynamic
32
TODO - Dan please help
33
If two agents share same physiological response, affect on receptor (either inhibition or activation)
34
If (from above) additive effects result in change in physiological response sufficent to result in adverse drug reaction
need to avoid minor but unimportant effects
35
36
Epidemiologic
37
#N/A
38
39
40
Management Support
41
#N/A
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100